

What is DMAE?
DMAE (Dimethylaminoethanol) is an organic compound with strong anti-inflammatory and aging reversal properties. It is found naturally in fish and also exists in the human nerve tissue. DMAE is a precursor to the stimulatory neurotransmitter acetylcholine, a chemical that stimulates nerve function and stimulates the muscles to contract and tighten under the skin.
As we age, our levels of acetylcholine decrease and this decline is associated with sagging skin as well as memory loss. Increasing your acetylcholine levels, either through application or supplementation is essential reverse the effects of aging.
How do we know that DMAE has an accumulative effect?
The American Journal of Clinical Dermatology reported the following in a placebo-controlled trial:
"In a randomized clinical study, 3% DMAE facial gel applied daily for 16 weeks has been shown to be safe and efficacious (p < 0.05) in the mitigation of forehead lines and periorbital fine wrinkles, and in improving lip shape and fullness and the overall appearance of aging skin. These effects did not regress during a 2-week cessation of application. Beneficial trends (p > 0.05 but 0.1) were noted in the appearance of coarse wrinkles, under-eye dark circles, nasolabial folds, sagging neck skin, and neck firmness...
Thus, the benefits of DMAE in dermatology include a potential anti-inflammatory effect and a documented increase in skin firmness with possible improvement in underlying facial muscle tone." —Excerpt from Abstract published in the American Journal of Clinical Dermatology 2005.
Another interesting study was performed by the University Medical Center of Liège in Belgium. They report that "the present 2-phase randomized double-blind split face study was designed to compare the effect of a gel containing 3% 2-dimethylaminoethanol (deanol, DMAE) with the same formulation without DMAE...
A second study conducted in 30 volunteers, shear wave propagation was measured... The DMAE formulation showed, however, a significant effect characterized by increased shear wave velocity in the direction where the mechanical anisotropy of skin showed looseness. CONCLUSION: The DMAE formulation under investigation increased skin firmness." —Excerpt as published in Skin Res Technol. August 2002
TESTIMONIALS: What our clients are saying about Two Timing Tightener - (Skin Biology's DMAE Tightening Serum)
"This should have been called FACE LIFT IN A BOTTLE. Love how it tightens up around my eyes, nose and mouth area. Fantastic! I am also doing Exfol and CP Serum could be that also, but I do notice a nice lift when I use this serum. I am happy with it. The difference is very noticeable for me. I just turned 47 and started to see some facial sagging in the usual places but it wasn't too bad. My husband even said my skin is smoother and brighter and I have only been doing the CP for 2 weeks." —G.L.
"Two Timing Tightener is one of the best skin products I have ever used. Used it for several months after it first released and then took a break for about 3 months. Didn't realize what effect it was having on overall skin firmness until I stopped using and went back to using it. Should, in my opinion be a part of everyone's arsenal." —B.E.
"I have been using it for about 2 weeks only AM I absolutely love it, the consistency is perfect not to runny not too thick. The tightening will progress I am most hopeful. It however is fantastic in reducing puffiness around the eye area. This one is a keeper." —M.Y.
"I also LOVE, LOVE, LOVE the Two Timing Tightener! It seems to really brighten up a little dark area under my eye. That will be a keeper for sure." —D.
"Two Timing Tightener helps with the tightening action, I use it all over my face & neck. Emu Oil on top of these products helps penetration & moisturizing the skin...(couldn't live without it!) My eyes look much better... I like using TTT after my CP Serum in the AM ALL OVER including the jawline...it helps in the tightening department." —S.Y.